In vitro testing of highly diluted cytokines and specific nucleotide acid sequences applied in micro-immunotherapy for rheumatoid arthritis

Background: TNF-α and IL-6 are key inflammatory factors in rheumatoid arthritis (RA) and constitute targets for the development of anti-inflammatory drugs. Rather than apply antagonist strategies, the micro-immunotherapy approach is based on the use of very low doses and highly diluted cytokines and specific nucleotide acid sequences (SNA®) which, administered sequentially, are intended to reduce synovial inflammation and to regulate auto-immune disorders associated with RA.

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