Background: Exhaustion, nervousness and decreased physical and mental capability are recurrent challenges in GPs’ daily routine. They are often resulting from overexertion, or disturbed sleep. Nowadays people feel exhausted and weak due to continuously increasing professional demands and rising challenges in daily life. The approved homeopathic medicinal product Manuia is used in the mentioned therapeutic area. It contains four single active substances: Damiana, Panax ginseng, Acidum phosphoricum and Ambra. So far, effectiveness and tolerability was confirmed by clinical experience, but systematically collected data were lacking.